Wow! Something's not quite right. I've been taking 1800 mcg of methyl folate and 1700 mcg of methyl B12 and I'm feeling deja vu. Flying, soaring, easily irritated, and I'm certain that I'm irritating to anyone who stands next to me. I should have known I was getting a bit loony when I streaked my dark brown hair with blond, then disliked it so strongly that rather than wait for my hair stylist to return to town, I covered it with a flat shade of brown.  My internal rhythms were pounding and beating way too fast.

I've been on the supplements for 6 months. For about five months I definitely had more energy, wasn't tired all the time. My vision improved so much that I can now read three lines lower on the doctor's eye chart than I did last year. I hear music undertones I've never heard before. Now I know why the Beatles are so amazing. I finally can hear why.

But for the past week or so I'm on edge as in the old days before I tool the blood test for MTHFR. What's going on?

Yesterday I took the remedy suggested for an overload of methyl folate, namely niacin to reduce SAMe that's a byproduct of too much methylation, I felt better within 5 minutes. So it must be too much.

According to Dr. Lynch at www.MTHFR.net, the side effects of too much are: irritability, insomnia, sore muscles, achy joints, acne, rash, severe anxiety, palpitations, nausea, headaches, migraines. Fortunately, I've been spared the rash, acne, insomnia, palpitations, headaches, and migraines.

Tomorrow I cut back to 1400 methyl folate and 700 B12. And if I'm still wired and anxious, I'll cut back even more the day after tomorrow. The essential thing for me to remember is to use the niacin if I get too feisty.

I wonder if a person at first needs to build up the body with methylation, then cut back after a while. I've alerted my family members who have the mutation to notice if they get too anxious or have other side effects so they can also cut back. But hurrah for methylation. I'll keep you posted.